Bryce Ratner-Keefly, a longtime talent leader with no technical background, talks through building and shipping a fitness app with AI tools, from rough prompts in Replit to App Store approval. Along the way, the conversation becomes a case study in beginner’s mindset, improvised workflows, and how quickly software building is slipping beyond the usual technical gatekeepers.

Oncologist and former Cancer Moonshot adviser Dr. Komal Megharajani talks through how AI is actually entering healthcare: not as a miracle cure, but as documentation help, clinical decision support and a new layer on top of physicians’ judgment. The conversation keeps one foot in policy and another in the clinic, tracing how evidence, training, regulation and lived experience shape what these tools can and cannot do.

Derek Thompson and Ross Douthat map the fractures opening inside Trump’s coalition as the Iran war strains the movement’s old promises and exposes its internal contradictions. Their conversation tracks the growing fights over foreign intervention, religion, Israel, health politics and AI, and asks what kind of Republican Party might survive after Trump.